解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The NFAR gene (nuclear factor associated with dsRNA) encodes a putative transcription-associated factor that we have shown is a substrate for the interferon-inducible, dsRNA-dependent protein kinase, PKR. However, our protein expression analysis has revealed that NFAR exists as two major protein species of 90 kDa (NFA...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6423
更新日期:2001-01-15 00:00:00
abstract::While scanning for single-nucleotide polymorphisms (SNPs) in the human Xq25-q28 region of CEPH families, we found six long "deserts" of low SNP incidence representing 28% of the investigated genome. One was 1.66 Mb in length. To determine whether these SNP deserts were due to reduced input of mutations or to recent co...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6417
更新日期:2001-01-01 00:00:00
abstract::As the exponential growth of DNA sequence information in databases continues, the task of converting this deposited information into knowledge becomes more dependent on integrative sequence analysis and visualization tools. PANORAMA is an Internet-accessible software package that performs a variety of informatics anal...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6359
更新日期:2000-12-15 00:00:00
abstract::Evi9, a common site of retroviral integration in BXH2 murine myeloid leukemias, encodes a C2H2 zinc finger protein and is overexpressed in these leukemic cells. To investigate a possible role of EVI9 in the human hematopoietic system, we isolated the cDNA clone of the human homologue. Human EVI9, located on the chromo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6385
更新日期:2000-12-15 00:00:00
abstract::Uroporphyrinogen-III (URO) synthase is the heme biosynthetic enzyme defective in congenital erythropoietic porphyria. The approximately 34-kb human URO-synthase gene (UROS) was isolated, and its organization and tissue-specific expression were determined. The gene had two promoters that generated housekeeping and eryt...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6373
更新日期:2000-12-01 00:00:00
abstract::The T-box is a strongly conserved protein domain, 174 to 186 amino acids in length, that binds DNA. Many genes from many species have been shown to encode T-box domain-containing proteins. Here we report the cloning and characterization of a novel T-box gene, TBX21. The human cDNA contains an open reading frame encodi...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6361
更新日期:2000-11-15 00:00:00
abstract::The adrenoleukodystrophy-related gene (ALDR, ABCD2) is a candidate modifier gene and a potential therapeutic target for X-linked adrenoleukodystrophy (ALD), a severe neurodegenerative disease. The ALDR gene is the closest homologue of the ALD gene, which encodes a peroxisomal ABC transporter involved in the catabolism...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6367
更新日期:2000-11-15 00:00:00
abstract::We have identified a novel human gene, designated C1orf10, using modified differential display PCR. The C1orf10 gene, which spans 5 kb in length, is composed of three exons. The deduced protein contains 495 amino acids with one transmembrane domain. The amino acid sequence of C1orf10 is characterized by the presence o...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6344
更新日期:2000-11-01 00:00:00
abstract::We investigated a family with a duplication, dup(X)q26-q27, that was present in two brothers, their mother, and their maternal grandmother. The brothers carrying the duplication displayed spina bifida and panhypopituitarism, whereas a third healthy brother inherited the normal X chromosome. Preferential inactivation o...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6327
更新日期:2000-10-15 00:00:00
abstract::LRP1B is a novel candidate tumor suppressor gene that is inactivated by genetic and transcript alterations in nearly 50% of non-small-cell lung cancer cell lines. The gene-encoded protein is highly homologous to the gigantic lipoprotein receptor-related protein 1 (LRP1) that belongs to the family of low-density lipopr...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6331
更新日期:2000-10-15 00:00:00
abstract::Williams-Beuren syndrome (WBS) is a developmental disorder caused by haploinsufficiency for genes deleted in chromosome band 7q11.23. A common deletion including at least 16-17 genes has been defined in the great majority of patients. We have completed a physical and transcription map of the WBS region based on analys...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6312
更新日期:2000-10-01 00:00:00
abstract::The SH2 domain containing inositol 5'-phosphatase (SHIP) was initially described as a 145-kDa protein phosphorylated on tyrosines upon growth factor and cytokine stimulation. It was shown to be phosphorylated after Fc and B cell receptor activation and plays a role in negative signaling. Different isoforms of the SHIP...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6324
更新日期:2000-10-01 00:00:00
abstract::Full-length coding sequences of two novel human cadherin cDNAs were obtained by sequence analysis of several EST clones and 5' and 3' rapid amplification of cDNA ends (RACE) products. Exons for a third cDNA sequence were identified in a public-domain human genomic sequence, and the coding sequence was completed by 3' ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6305
更新日期:2000-09-15 00:00:00
abstract::Glomerulopathy with fibronectin deposits (GFND, MIM 601894) is an autosomal dominant kidney disease that leads to terminal renal failure at a median age of 47 years. It represents a distinct entity of membranoproliferative glomerulonephritis (MPGN) type III and is characterized by the unique feature of massive glomeru...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6292
更新日期:2000-09-01 00:00:00
abstract::Primary pulmonary hypertension (PPH), an often fatal disorder, is characterized by sustained elevation of pulmonary artery pressure of unknown cause. In its familial form (FPPH), the disorder segregates as an autosomal dominant and displays markedly reduced penetrance. A gene for FPPH was previously localized to a 25-...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6291
更新日期:2000-09-01 00:00:00
abstract::The gene encoding activation-induced cytidine deaminase (AID), a member of the cytidine deaminase family, was isolated from a murine B cell lymphoma line, CH12F3-2, induced by combined stimulation of TGF-beta, IL-4, and CD40L. We have isolated the human orthologue of mouse AID cDNA, which has an open reading frame of ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6268
更新日期:2000-08-15 00:00:00
abstract::The ST2 gene is a member of the IL-1 receptor family and is hypothesized to be involved in helper T cell function, but its functional ligand and physiological role remain unknown. We have cloned the human ST2L cDNA that encodes a distinct type of membrane-bound ST2 protein. The predicted 556-amino-acid sequence showed...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6269
更新日期:2000-08-01 00:00:00
abstract::Mutations in the DKC1 gene are responsible for causing X-linked recessive dyskeratosis congenita (DKC) and a more severe allelic variant of the disease, Hoyeraal-Hreidarsson syndrome. Both diseases are characterized by progressive and fatal bone marrow failure. The nucleolar protein dyskerin is the pseudouridine synth...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6227
更新日期:2000-07-15 00:00:00
abstract::Oncogenic hypophosphatemic osteomalacia (OHO) is characterized by a renal phosphate leak, hypophosphatemia, low-serum calcitriol (1,25-vitamin-D3), and abnormalities in skeletal mineralization. Resection of OHO tumors results in remission of the symptoms, and there is evidence that a circulating phosphaturic factor pl...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6235
更新日期:2000-07-01 00:00:00
abstract::Biologic effects of androgen on target cells are mediated in part by transcriptional regulation of androgen-regulated genes (ARGs) by androgen receptor. Using serial analysis of gene expression (SAGE), we have identified a comprehensive repertoire of ARGs in LNCaP cells. One of the SAGE-derived tags exhibiting homolog...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6214
更新日期:2000-06-15 00:00:00
abstract::Childhood-onset asthma is frequently found in association with atopy. Although asthmatic children may develop IgE antibodies against variety of allergens, asthma is associated primarily with allergy to house-dust mites, molds, or other allergens. In this study, we conducted a genome-wide linkage search in 47 Japanese ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6201
更新日期:2000-06-01 00:00:00
abstract::Unbalanced chromosome translocations with breakpoints around 8p12, resulting in loss of distal 8p, are common in carcinomas. We have mapped the 8p12 breakpoints in three breast cancer cell lines, T-47D, MDA-MB-361, and ZR-75-1, using YACs and PACs between D8S540 and D8S255 by fluorescence in situ hybridization. All th...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6178
更新日期:2000-05-15 00:00:00
abstract::The human genome harbors thousands of long terminal repeats (LTRs) that are derived from endogenous retroviruses and contain elements able to regulate the expression of neighboring cellular genes. We have investigated the ability of human endogenous retroviral (HERV)-K LTRs to provide transcriptional processing signal...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6175
更新日期:2000-05-15 00:00:00
abstract::The human DAZ (deleted in azoospermia) gene family on the Y chromosome and an autosomal DAZ-like gene, DAZL1, encode RNA-binding proteins that are expressed exclusively in germ cells. Their role in spermatogenesis is supported by their homology with a Drosophila male infertility gene boule and sterility of Daz11 knock...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6169
更新日期:2000-05-01 00:00:00
abstract::We developed a sequence-ready physical map of a part of human chromosome 12p12.3-p13.2 where the natural killer gene complex (NKC) is located. The NKC includes a cluster of genes with structure similar to that of the Ca(2+)-dependent lectin superfamily of glycoproteins that are expressed on the surface of most natural...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6163
更新日期:2000-04-15 00:00:00
abstract::The large number of redundant sequences available in nucleotide databases provides a resource for the identification of polymorphisms. Expressed polymorphisms in X-linked genes can be used to determine the inactivation status of the genes, and polymorphisms in genes that are subject to inactivation can then be used as...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6153
更新日期:2000-04-01 00:00:00
abstract::The rat diabetes susceptibility gene, Lyp or Lymphopenia, has been localized to RNO4. Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene. In human, the three genes are syntenic on HSA7, but they are not on a conserved seg...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6130
更新日期:2000-04-01 00:00:00
abstract::The chromosomal abnormality represented by an isodicentric X chromosome [idic(X)(q13)] is associated with a subset of acute myeloid leukemia (AML) and preleukemia observed in elderly females. A previous study localized the breakpoints of two acquired isodicentric X chromosomes associated with myelodysplasia to a 450-k...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6128
更新日期:2000-03-15 00:00:00
abstract::IB1/JIP-1 is a scaffold protein that regulates the c-Jun NH(2)-terminal kinase (JNK) signaling pathway, which is activated by environmental stresses and/or by treatment with proinflammatory cytokines including IL-1beta and TNF-alpha. The JNKs play an essential role in many biological processes, including the maturatio...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6129
更新日期:2000-03-15 00:00:00
abstract::The two contiguous IGF2 (human insulin-like growth factor II) and H19 genes are reciprocally imprinted in both human and mouse. In most tissues, IGF2 is transcribed only from the paternal chromosome while H19 is transcribed only from the maternal allele. The presence of a differential methylation region (DMR) on the t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6094
更新日期:2000-03-01 00:00:00
abstract::The Drosophila melanogaster small optic lobes gene (sol) is required for normal development of the neuropiles of the medulla and lobula complexes of the adult optic lobes. The predicted protein products of sol and its human homologue SOLH contain zinc-finger-like repeats, a calpain-like protease domain, and a C-termin...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6098
更新日期:2000-02-15 00:00:00
abstract::End sequences from bacterial artificial chromosomes (BACs) provide highly specific sequence markers in large-scale sequencing projects. To date, we have generated >300,000 end sequences from >186,000 human BAC clones with an average read length of >460 bp for a total of 141 Mb covering approximately 4.7% of the genome...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6082
更新日期:2000-02-01 00:00:00
abstract::Several projects have produced maps of the physical position of genes within the human genome, either on a genome-wide scale or of a more detailed subsection of a chromosome. However, these maps largely rely on the mapping of expressed sequences (cDNAs and ESTs) back onto physical maps by their localization onto speci...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6075
更新日期:2000-02-01 00:00:00
abstract::The alpha-fetoprotein (AFP) gene is transcribed at high levels in the fetal liver and is repressed at birth, leading to low but detectable levels of AFP mRNA in the adult liver. This repression is regulated, in part, by a locus that is unlinked to AFP called Alpha-fetoprotein regulator 1 (Afr1). Previous studies showe...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6073
更新日期:2000-01-15 00:00:00
abstract::Homeodomain transcription factors control cell fates during the development of all animals. The paired-like subfamily of homeodomain proteins has been particularly implicated in ocular development in different species. In this paper we report the cDNA sequence, genomic structure, localization, and expression data of a...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6093
更新日期:2000-01-15 00:00:00
abstract::Consecutive application of PCR and serial analysis of gene expression (SAGE) was used to generate a catalog of approximately 50, 000 SAGEtags from nine human oocytes. Matches for known genes were identified using the National Institutes of Health SAGEtag database. This database links directly to the UniGene database, ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6059
更新日期:2000-01-01 00:00:00
abstract::SOX proteins are transcription factors that are characterized by a common DNA-binding motif known as the HMG domain. We describe the 5. 4-kb human SOX8 gene that codes for a 446-amino-acid protein and that is expressed strongly in brain and less abundantly in other tissues. SOX8 shows an overall identity of 47% to SOX...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6060
更新日期:2000-01-01 00:00:00
abstract::Large deletions in Xq21 often are associated with contiguous gene syndromes consisting of X-linked deafness type 3 (DFN3), mental retardation (MRX), and choroideremia (CHM). The identification of deletions associated with classic CHM or DFN3 facilitated the positional cloning of the underlying genes, REP-1 and POU3F4,...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6004
更新日期:1999-12-15 00:00:00
abstract::The human XPF protein, an endonuclease subunit essential for DNA excision repair, may also function in homologous recombination. To investigate a possible link between mammalian XPF and recombination that occurs during meiosis, we isolated, characterized, and determined an expression profile for the mouse Xpf gene. Th...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6016
更新日期:1999-12-15 00:00:00
abstract::The genes encoding human U2 small nuclear RNA are arrayed in tandem (the RNU2 locus) and have undergone concerted evolution for >35 Myr. Tandem organization of repetitive sequences may facilitate recombination that underlies concerted evolution, but could risk instability. Since DNA methylation plays a crucial role in...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6052
更新日期:1999-12-15 00:00:00